A devastating explosion has reportedly ripped through a multi-storey police headquarters in Turkey’s southeastern province of Diyarbakir, killing five people and wounding 39 others.

The incident occurred late on Wednesday when an explosive-laden car hit the headquarters in Cinar district and totally destroyed its entire facade, the Turkish Daily Sabah reported, adding that the building was then attacked with “rocket launchers and long barreled weapons.”

The huge blast also inflicted damage to nearby buildings, and set the whole headquarters on a raging fire.

Backup police units and soldiers have been deployed to the blast site along with ambulances and paramedics. The injured were taken to a nearby hospital.

The Turkish media has blamed the attack on militants belonging to the Kurdistan Workers' Party (PKK).

The Tuesday blast, blamed on the Daesh Takfiri terrorist group, took place in Istanbul's historic Sultanahmet Square, a major tourist attraction, killing at least 10 foreigners, including nine German tourists. Fifteen other people also sustained injuries.

Since late July 2015, Turkey’s southeastern regions have witnessed a spike in violence amid heavy confrontations between army forces and the PKK, an outlawed group that have been fighting for an autonomous Kurdish region inside Turkey since the 1980s. Ankara’s military has also been involved in an offensive against positions of the Kurdish group in neighboring Iraq.